全身麻醉药对蜗牛中枢神经系统中乙酰胆碱诱导抑制的作用。
The action of general anaesthetics on acetylcholine-induced inhibition in the central nervous system of Helix.
作者信息
Judge S E, Norman J
出版信息
Br J Pharmacol. 1982 Feb;75(2):353-7. doi: 10.1111/j.1476-5381.1982.tb08793.x.
Abstract
The effects of general anaesthetics, thiopentone, etomidate, minaxolone and ketamine were studied on identified voltage-clamped neurones of Helix aspersa. At concentrations of 0.1-0.5 mM, thiopentone, etomidate and minaxolone had no effect on the resting conductance of identified cells, D1 and D2. Ketamine at a concentration of 0.1-0.5 mM depolarized and excited the cells. All four anaesthetics tested depressed a chloride-dependent inhibitory response to acetylcholine (ACh) in cells D1 and D2 at concentrations of 0.1-0.5 mM in a dose-dependent and reversible manner with no change in the reversal potential of the response. These results show that general anaesthetics can block the transmitter-evoked chloride-mediated increases in membrane conductance in Helix neurones.
摘要
研究了全身麻醉药硫喷妥钠、依托咪酯、米那索龙和氯胺酮对已鉴定的皱唇螺电压钳制神经元的作用。在0.1 - 0.5 mM的浓度下，硫喷妥钠、依托咪酯和米那索龙对已鉴定的细胞D1和D2的静息电导没有影响。浓度为0.1 - 0.5 mM的氯胺酮使细胞去极化并兴奋。所测试的所有四种麻醉药在0.1 - 0.5 mM的浓度下，均以剂量依赖性和可逆的方式抑制了细胞D1和D2中对乙酰胆碱（ACh）的氯离子依赖性抑制反应，且反应的反转电位没有变化。这些结果表明，全身麻醉药可以阻断递质诱发的皱唇螺神经元中氯离子介导的膜电导增加。
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