全身麻醉药与皮质神经元的乙酰胆碱敏感性
General anaesthetics and the acetylcholine-sensitivity of cortical neurons.
作者信息
Smaje J C
出版信息
Br J Pharmacol. 1976 Nov;58(3):359-66. doi: 10.1111/j.1476-5381.1976.tb07712.x.
Abstract
1The effects of general anaesthetics on neuronal responses to iontophoretically-applied acetylcholine have been examined in slices of guinea-pig olfactory cortex maintained in vitro. 2 Acetylcholine excited 61% of the prepiriform neurones tested. The excitation was blocked by atropine, but not by dihydro-beta-erythroidine or gallamine. 3 Alphaxalone reversibly depressed the acetylcholine-sensitivity of prepiriform neurones. Pentobarbitone did not consistently depress the acetylcholine sensitivity of these cells. 4 Ether, methoxyflurane, trichloroethylene and halothane caused a dose-related augmentation of acetylcholine-induced firing. 5 These results show that general anaesthetics do not necessarily depress the sensitivity of nerve cells to all excitatory substances and that different anaesthetics may affect a particular excitatory process in various ways.
摘要
- 已经在体外培养的豚鼠嗅皮质切片中研究了全身麻醉药对离子电泳施加乙酰胆碱时神经元反应的影响。2. 乙酰胆碱使61%的受试梨状前区神经元兴奋。这种兴奋被阿托品阻断，但不被二氢β-刺桐碱或加拉明阻断。3. 阿法沙龙可逆地降低梨状前区神经元对乙酰胆碱的敏感性。戊巴比妥并不始终降低这些细胞对乙酰胆碱的敏感性。4. 乙醚、甲氧氟烷、三氯乙烯和氟烷引起与剂量相关的乙酰胆碱诱发放电增强。5. 这些结果表明，全身麻醉药不一定会降低神经细胞对所有兴奋性物质的敏感性，而且不同的麻醉药可能以不同方式影响特定的兴奋过程。
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本文引用的文献
1
Pharmacological properties of acetylcholine-sensitive cells in the cerebral cortex.大脑皮层中乙酰胆碱敏感细胞的药理学特性。
J Physiol. 1963 May;166(2):328-50. doi: 10.1113/jphysiol.1963.sp007107.
2
THE EXCITATION OF THALAMIC NEURONES BY ACETYLCHOLINE.乙酰胆碱对丘脑神经元的兴奋作用。
Acta Physiol Scand. 1964 May-Jun;61:85-99. doi: 10.1111/j.1748-1716.1964.tb02945.x.
3
The pharmacology of neurones in the pyriform cortex.梨状皮质中神经元的药理学
Br J Pharmacol Chemother. 1966 Jan;26(1):87-107. doi: 10.1111/j.1476-5381.1966.tb01814.x.
4
Pharmacological studies on feline Betz cells.猫贝茨细胞的药理学研究。
J Physiol. 1966 Sep;186(1):121-38. doi: 10.1113/jphysiol.1966.sp008024.
5
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J Physiol. 1971 May;215(1):247-68. doi: 10.1113/jphysiol.1971.sp009467.
6
Calcium, magnesium and the electrical activity of guinea-pig olfactory coex in vitro.豚鼠嗅球体外培养物中的钙、镁与电活动
J Physiol. 1970 Dec;211(3):571-84. doi: 10.1113/jphysiol.1970.sp009294.
7
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8
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Can J Physiol Pharmacol. 1972 Nov;50(11):1111-4. doi: 10.1139/y72-162.
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