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Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response.

作者信息

Ardalan B, Buscaglia M D, Schein P S

出版信息

Biochem Pharmacol. 1978;27(16):2009-13. doi: 10.1016/0006-2952(78)90059-x.

DOI:10.1016/0006-2952(78)90059-x
PMID:718724
Abstract
摘要

相似文献

1
Tumor 5-fluorodeoxyuridylate concentration as a determinant of 5-fluorouracil response.肿瘤5-氟脱氧尿苷酸浓度作为5-氟尿嘧啶反应的决定因素。
Biochem Pharmacol. 1978;27(16):2009-13. doi: 10.1016/0006-2952(78)90059-x.
2
Pharmacodynamics of 5-fluorouracil and leucovorin.5-氟尿嘧啶和亚叶酸的药效学
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3
Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations.
Cancer. 1981 Mar 15;47(6):1313-7. doi: 10.1002/1097-0142(19810315)47:6<1313::aid-cncr2820470613>3.0.co;2-o.
4
Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors.
Cancer Res. 1978 Aug;38(8):2325-31.
5
Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma.序贯甲氨蝶呤/5-氟尿嘧啶：可移植性啮齿动物结肠腺癌中FdUMP的形成及胸苷酸合成酶抑制作用
Cancer Chemother Pharmacol. 1986;16(3):237-42. doi: 10.1007/BF00293984.
6
Phosphoribosyl pyrophosphate, pool size and tissue levels as a determinant of 5-fluorouracil response in murine colonic adenocarcinomas.
Biochem Pharmacol. 1982 Jun 1;31(11):1989-92. doi: 10.1016/0006-2952(82)90410-5.
7
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.关于氟嘧啶对免疫缺陷小鼠体内四种人结肠腺癌异种移植瘤的细胞毒性作用机制
Cancer. 1980 Mar 15;45(5 Suppl):1159-67. doi: 10.1002/1097-0142(19800315)45:5+<1159::aid-cncr2820451320>3.0.co;2-z.
8
Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.5-氟尿嘧啶给药后，人结肠腺癌异种移植瘤中5-氟-2'-脱氧尿苷酸、2'-脱氧尿苷酸与胸苷酸合成酶活性之间的关系。
Biochem Pharmacol. 1986 Apr 15;35(8):1351-8. doi: 10.1016/0006-2952(86)90281-9.
9
Binding of 5-fluorodeoxyuridylate to thymidylate synthase in human colon adenocarcinoma xenografts.5-氟脱氧尿苷酸与人结肠腺癌异种移植瘤中胸苷酸合成酶的结合。
Eur J Cancer Clin Oncol. 1986 Apr;22(4):505-10. doi: 10.1016/0277-5379(86)90119-7.
10
Modulation of fluoropyrimidine metabolism by chlorpromazine.氯丙嗪对氟嘧啶代谢的调节作用。
Biochem Biophys Res Commun. 1986 Jul 31;138(2):1009-14. doi: 10.1016/s0006-291x(86)80596-4.

引用本文的文献

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Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2'-Bipyridyl.4,6-二氨基-5-羟基-2-巯基嘧啶与2,2'-联吡啶混合配体钯（II）和银（I）配合物的合成、光谱性质及抗癌性能
Met Based Drugs. 2008;2008:723634. doi: 10.1155/2008/723634.
2
Antitumor activity of novel N-sulfonylpyrimidine derivatives on the growth of anaplastic mammary carcinoma in vivo.新型N-磺酰基嘧啶衍生物对间变性乳腺癌体内生长的抗肿瘤活性。
J Cancer Res Clin Oncol. 2005 Dec;131(12):829-36. doi: 10.1007/s00432-005-0026-z. Epub 2005 Nov 15.
3
Effect of concurrent calcium leucovorin infusion on 5-fluorouracil cytotoxicity against murine L1210 leukemia.
Cancer Chemother Pharmacol. 1981;6(2):121-5. doi: 10.1007/BF00262328.
4
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Cancer Chemother Pharmacol. 1984;13(2):86-90. doi: 10.1007/BF00257120.
5
Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma.序贯甲氨蝶呤/5-氟尿嘧啶：可移植性啮齿动物结肠腺癌中FdUMP的形成及胸苷酸合成酶抑制作用
Cancer Chemother Pharmacol. 1986;16(3):237-42. doi: 10.1007/BF00293984.
6
The role of fluorinated pyrimidine analogues in the induction of the in vitro expression of the fragile X chromosome.氟代嘧啶类似物在诱导脆性X染色体体外表达中的作用。
Hum Genet. 1988 Aug;79(4):341-6. doi: 10.1007/BF00282173.
7
Cellular pharmacology of fluorinated pyrimidines in vivo in man.
Invest New Drugs. 1989 Apr;7(1):13-25. doi: 10.1007/BF00178188.
8
Clinical pharmacology of 5-fluorouracil.5-氟尿嘧啶的临床药理学
Clin Pharmacokinet. 1989 Apr;16(4):215-37. doi: 10.2165/00003088-198916040-00002.
9
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.肿瘤对5-氟尿嘧啶敏感性的生化决定因素：测定5-氟-2'-脱氧尿苷酸、2'-脱氧尿苷酸和胸苷酸合成酶的超灵敏方法。
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1456-60. doi: 10.1073/pnas.76.3.1456.