Barlet J P, Davicco M J, Lefaivre J
J Physiol (Paris). 1982;78(9):809-13.
Nine single foetal lambs with catheters chronically implanted in utero on day 122 of gestation into the left carotid artery, the right external jugular vein and the bladder were used. In these foetuses, between days 130 and 142 of gestation, urine flow rate was 0.48 +/- 0.09 ml X min-1. In the same time, an intravenous infusion of bovine parathyroid hormone (150 U per foetus in 30 min) induced hypercalcaemia and hypophosphataemia, associated with an increase in urinary flow rate and urinary phosphate concentration. Although urinary calcium concentration was unchanged, the urinary excretion of both calcium and phosphate increased. An intravenous infusion of salmon calcitonin (200 MRC mU per foetus in 30 min) induced hypocalcaemia and hypophosphataemia, associated with an increased urinary phosphate concentration. Urinary flow rate and urinary calcium concentration were not modified by the calcitonin which increased only urinary excretion of phosphate. Thus the high plasma phosphate levels measured in lambs during the perinatal period do not seem to be related to a previous unresponsiveness (just before birth) to the hormones regulating phosphate urinary excretion.
选用9只妊娠122天时在子宫内长期植入导管的单胎羔羊，导管分别植入左颈动脉、右颈外静脉和膀胱。在这些胎儿中，妊娠130至142天期间，尿流率为0.48±0.09 ml×min⁻¹。同时，静脉输注牛甲状旁腺激素（每只胎儿30分钟内输注150 U）可引起高钙血症和低磷血症，并伴有尿流率和尿磷浓度增加。虽然尿钙浓度未变，但钙和磷的尿排泄量均增加。静脉输注鲑鱼降钙素（每只胎儿30分钟内输注200 MRC mU）可引起低钙血症和低磷血症，并伴有尿磷浓度增加。降钙素仅增加磷的尿排泄量，而尿流率和尿钙浓度未受影响。因此，在围产期羔羊中测得的高血浆磷水平似乎与之前（出生前）对调节磷尿排泄的激素无反应无关。
