Smith G, Dalling R, Williams T I
Br J Anaesth. 1978 Nov;50(11):1137-43.
The pressures in the lower oesophageal sphincter (high pressure zone or HPZ) and stomach were measured in 15 patients with duodenal ulcer and 14 patients with no gastrointestinal disease. All the patients were premedicated with morphine 10 mg i.m. In the patients without duodenal ulcer, the pressure gradient between HPZ and stomach was 6.6 +/- 0.62 mm Hg (mean +/- SEM) before diminishing to 4.9 +/- 0.86 after induction of anaesthesia with thiopentone. During fasciculations following i.v. suxamethonium, the gradient increased to 7.1 +/- 1.0 mm Hg. In patients with duodenal ulcer, although the absolute pressures were less, the gradients during the study were similar to those in healthy patients. We conclude that there is no increased risk of regurgitation during fasciculations induced by suxamethonium.
对15例十二指肠溃疡患者和14例无胃肠道疾病的患者测量了食管下括约肌（高压区或HPZ）和胃内压力。所有患者均预先肌内注射10mg吗啡。在无十二指肠溃疡的患者中，HPZ与胃之间的压力梯度在硫喷妥钠麻醉诱导前为6.6±0.62mmHg（平均值±标准误），麻醉诱导后降至4.9±0.86。静脉注射琥珀胆碱后出现肌束颤动时，压力梯度增至7.1±1.0mmHg。十二指肠溃疡患者虽然绝对压力较低，但研究期间的压力梯度与健康患者相似。我们得出结论，琥珀胆碱诱导的肌束颤动期间反流风险没有增加。
