Duignan N M, Shaw R W, Glass M R, Butt W R, Edwards R L
Br J Obstet Gynaecol. 1978 Nov;85(11):862-7. doi: 10.1111/j.1471-0528.1978.tb15844.x.
Premature ovarian failure was studied in ten women under the age of 30; eight had an ovarian biopsy and five of these showed primordial follicles. Plasma levels of oestradiol and progesterone were similar to the follicular phase of a normal menstrual cycle, but in eight patients cervical smears showed a cornification index of less than one per cent. Levels of both androgens and of sex hormone binding globulin capacity were generally normal. Administration of LH-RH caused a release of FSH which was similar to post menopausal women and higher than both. Two patients were treated with exogenous gonadotrophins without effect.
对10名30岁以下的女性进行了卵巢早衰研究；其中8人进行了卵巢活检，5人显示有原始卵泡。雌二醇和孕酮的血浆水平与正常月经周期的卵泡期相似，但8名患者的宫颈涂片显示角化指数低于1%。雄激素和性激素结合球蛋白水平总体正常。注射促黄体生成素释放激素（LH-RH）后促卵泡生成素（FSH）的释放与绝经后女性相似，且高于两者。两名患者接受外源性促性腺激素治疗但无效。
