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血浆碱性核糖核酸酶(EC 3.1.4.22)与低体重儿的氮潴留

Plasma alkaline ribonuclease (EC 3.1.4.22) and nitrogen retention in low-birth-weight infants.

作者信息

Scott P H, Berger H M, Kenward C, Scott P, Wharton B A

出版信息

Br J Nutr. 1978 Nov;40(3):459-64. doi: 10.1079/bjn19780147.

DOI:10.1079/bjn19780147
PMID:718828
Abstract
  1. Nitrogen retention was determined by classical N balance techniques in fourteen rapidly growing low-birth-weight infants receiving 3 g protein/kg body-weight and during their 3rd week of life. This was compared with plasma free alkaline ribonuclease (EC 3.I.4.22; RNase) activity and other biochemical measurements of protein nutrition. 2. Plasma RNase showed a significant positive correlation with N retention and a corresponding negative correlation with urine urea-N. These results were unexpected and suggest a different relationship between RNase and N retention in infants compared with that found by other workers in children and adults. 3. The most likely explanation of this apparent anomaly is that in all instances high activities of plasma RNase are associated with a need to conserve N. In the infants studied this may indicate some measure of 'protein economy' and they could therefore benefit from a higher protein intake.
摘要
  1. 通过经典氮平衡技术,对14名快速生长的低体重婴儿在出生后第3周接受3克蛋白质/千克体重时的氮潴留情况进行了测定。并将其与血浆游离碱性核糖核酸酶(EC 3.I.4.22;RNase)活性以及蛋白质营养的其他生化指标进行了比较。2. 血浆核糖核酸酶与氮潴留呈显著正相关,与尿尿素氮呈相应的负相关。这些结果出人意料,表明与其他研究儿童和成人的工作者所发现的情况相比,核糖核酸酶与婴儿氮潴留之间存在不同的关系。3. 对这一明显异常现象最可能的解释是,在所有情况下,血浆核糖核酸酶的高活性都与氮的保存需求有关。在所研究的婴儿中,这可能表明某种程度的“蛋白质节约”,因此他们可能会从更高的蛋白质摄入量中受益。

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引用本文的文献

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Dig Dis Sci. 1982 Oct;27(10):889-96. doi: 10.1007/BF01316572.
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Br Med J (Clin Res Ed). 1982;285(6342):589-92. doi: 10.1136/bmj.285.6342.589.