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体外大鼠大脑皮层和海马体切片中内源性γ-氨基丁酸的释放

Endogenous GABA release from slices of rat cerebral cortex and hippocampus in vitro.

作者信息

Fan S G, Lee C M, Assaf S Y, Iversen L L

出版信息

Brain Res. 1982 Mar 11;235(2):265-70. doi: 10.1016/0006-8993(82)91006-x.

DOI:10.1016/0006-8993(82)91006-x
PMID:7188328
Abstract

Using a rapid, simple and sensitive radioreceptor assay, a Ca2+-dependent K+-evoked release of endogenous GABA was demonstrated from rat cortical and hippocampal slices in vitro. This evoked-release of endogenous GABA was similar to that of [3H]GABA release (in its Ca2+ dependency) but differed from the latter in having a higher signal to noise level. Neither 5-HT nor a stable enkephalin analogue had any effect on endogenous GABA release from hippocampus slices.

摘要

利用一种快速、简单且灵敏的放射受体分析法，在体外从大鼠皮质和海马切片中证实了内源性γ-氨基丁酸（GABA）的钙依赖性钾离子诱发释放。内源性GABA的这种诱发释放与[3H]GABA释放（在其对钙的依赖性方面）相似，但在信噪比水平更高方面与后者不同。5-羟色胺（5-HT）和一种稳定的脑啡肽类似物均对海马切片中内源性GABA的释放没有任何影响。

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