Tanaka N, Ogawa H, Tanaka K, Kinjo M, Kohga S
Invasion Metastasis. 1981;1(3):149-57.
When Lewis lung carcinoma with low thromboplastic and low fibrinolytic activities was implanted subcutaneously to mice, administration of tranexamic acid inhibited metastasis formation in the lungs. This effect was considered to be mediated by prevention of cell release from the implanted sites. Fibrin formation around tumor cells in the vessels of primary foci was observed in the mice given tranexamic acid. On the other hand, urokinase significantly enhanced pulmonary metastases and many free tumor cells were observed intravascularly in primary foci of the mice given urokinase.
将具有低促凝血活性和低纤维蛋白溶解活性的Lewis肺癌皮下植入小鼠体内时，给予氨甲环酸可抑制肺部转移灶的形成。这种作用被认为是通过防止肿瘤细胞从植入部位释放来介导的。在给予氨甲环酸的小鼠的原发灶血管中观察到肿瘤细胞周围有纤维蛋白形成。另一方面，尿激酶显著增强了肺转移，在给予尿激酶的小鼠的原发灶血管内观察到许多游离的肿瘤细胞。
