Kosugi T, Huang G W, Nakamura M, Koja S, Nong H T
Department of Physiology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Eur Arch Otorhinolaryngol. 1990;247(6):374-8. doi: 10.1007/BF00179011.
The activity of plasminogen activator (PA) in tissue extracts from nasopharyngeal carcinoma (NPC) was determined by means of the fibrin plate method. Development of PA activity was observed in 16 out of 25 cases investigated. Furthermore, using tissue extract of NPC with PA activity, characterization and identification of the activator were carried out by means of electrophoretic analysis, fibrin zymography and immunological analysis. The molecular weight of this PA was found to be 38,000 daltons. Additionally, a urokinase type of plasminogen activator was contained in the tissue extracts.
采用纤维蛋白平板法测定了鼻咽癌（NPC）组织提取物中纤溶酶原激活物（PA）的活性。在所研究的25例病例中，有16例观察到PA活性增强。此外，利用具有PA活性的NPC组织提取物，通过电泳分析、纤维蛋白酶谱分析和免疫分析对激活物进行了特性鉴定。发现该PA的分子量为38000道尔顿。此外，组织提取物中含有尿激酶型纤溶酶原激活物。
