Dodson W E
Neurology. 1980 Feb;30(2):196-9. doi: 10.1212/wnl.30.2.196.
The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations between 10 to 20 mg per liter, the average t50% (18.6 hours) was approximately 58% as long as the average in adults with comparable concentrations. Whereas the t50% correlated with the initial PHT concentrations, there was no correlation overall between t50% and age, size, or number of other antiepileptic medications taken. The concentration-dependence of the t50% provided the basis for less frequent dosing than one would expect from previous studies of PHT half-life in children with low concentrations.
在年龄从1天到22岁的婴儿、儿童和青年中评估了苯妥英（PHT）浓度对PHT消除率的影响。随着PHT浓度的增加，有效半衰期（t50%）延长。在8名年龄为7个月至4.83岁、初始浓度在每升10至20毫克之间的儿童中，平均t50%（18.6小时）约为浓度相当的成年人平均t50%的58%。虽然t50%与初始PHT浓度相关，但总体上t50%与年龄、体型或服用的其他抗癫痫药物数量之间没有相关性。t50%的浓度依赖性为比以前对低浓度儿童PHT半衰期研究预期的给药频率更低提供了依据。
