儿童苯妥英钠的药代动力学

Phenytoin kinetics in children.

作者信息

Dodson W E

出版信息

Clin Pharmacol Ther. 1980 May;27(5):704-7. doi: 10.1038/clpt.1980.100.

DOI:10.1038/clpt.1980.100

Abstract

Infants and children taking phenytoin by mouth every 12 hr had relatively little fluctuations in serum levels measured every 4 hr after a dose. As the average level rose, the relative fluctuation in level was reduced, consistent with nonlinear elimination kinetics. Levels 8 hr after the dose had the least variability and were 104% of the average level over the 12-hr period.

摘要

每12小时口服苯妥英钠的婴幼儿，在给药后每4小时测量的血清水平波动相对较小。随着平均水平的升高，水平的相对波动减小，这与非线性消除动力学一致。给药后8小时的水平变异性最小，是12小时期间平均水平的104%。