Curless R G, Walson P D, Carter D E
Neurology. 1976 Aug;26(8):715-20. doi: 10.1212/wnl.26.8.715.
Previous studies have shown the importance of phenytoin kinetics in the management of adult patients with seizure disorders. The long half-life in adults makes single daily dosing realistic in terms of blood levels and anticonvulsant effectiveness. This report shows a wide range in both half-lives and volumes of distribution of phenytoin in 11 children (ages 6 months to 6 years) with seizure disorders. Ten of these patients have very short phenytoin half-lives (1.2 to 6.7 hours). The data strongly suggest that current recommendations for phenytoin dosage regimens in adults cannot necessarily be used in children. Blood levels must be followed closely in this age group to determine the required dosage and dose interval.
先前的研究已经表明苯妥英动力学在成年癫痫患者治疗中的重要性。成年人较长的半衰期使得每日单次给药在血药浓度和抗惊厥疗效方面切实可行。本报告显示，11例患有癫痫症的儿童（年龄从6个月至6岁）的苯妥英半衰期和分布容积范围很广。其中10例患者的苯妥英半衰期非常短（1.2至6.7小时）。这些数据有力地表明，目前针对成年人的苯妥英给药方案建议不一定适用于儿童。对于这个年龄组的患者，必须密切监测血药浓度，以确定所需剂量和给药间隔。
