Munnell J F, Cork L C
Am J Pathol. 1980 Feb;98(2):385-94.
Scanning and transmission electron-microscopic study of the livers of 2 kittens suffering from GM2 gangliosidosis revealed discontinuities in the plasma membrane of hepatocytes and Kupffer cells, indicating an attempt by the cells to free themselves of excess lysosomal residues by means of exocytosis. Inclusions morphologically similar to those seen in the hepatocytes were observed in the perisinusoidal space. Openings were seen on all surfaces of the hepatocytes. Such extrusion of lysosomal residues is an example of a mechanism rarely observed in viable metazoan cells.
对2只患有GM2神经节苷脂沉积症的小猫肝脏进行扫描电镜和透射电镜研究发现，肝细胞和库普弗细胞的质膜存在间断，这表明细胞试图通过胞吐作用清除多余的溶酶体残留物。在窦周隙中观察到形态上与肝细胞中所见相似的包涵体。在肝细胞的所有表面都可见开口。这种溶酶体残留物的挤出是在存活的后生动物细胞中很少观察到的一种机制的实例。
