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地西泮和氟哌利多对发情期大鼠子宫影响的初步体外研究。

Preliminary in vitro study of diazepam and droperidol on oestrus rat uterus.

作者信息

Khan A A

出版信息

Br J Anaesth. 1980 Mar;52(3):349-54. doi: 10.1093/bja/52.3.349.

DOI:10.1093/bja/52.3.349
PMID:7189403
Abstract

The actions of diazepam and droperidol were studied on the spontaneously active and oxytocin-treated oestrus rat uterus. Both drugs significantly depressed the frequency of uterine contraction. Droperidol reduced the amplitude of contractions and the basal tone of the tissue. The sensitivity of the tissue to both drugs was enhanced in the presence of the smallest concentration of oxytocin (0.2 mu. ml-1). Prior exposure of the tissue to droperidol sensitized the muscle to oxytocin.

摘要

研究了地西泮和氟哌利多对自发活动及经催产素处理的发情期大鼠子宫的作用。两种药物均显著降低子宫收缩频率。氟哌利多降低了收缩幅度和组织的基础张力。在存在最小浓度催产素（0.2微克/毫升）的情况下，组织对两种药物的敏感性增强。预先将组织暴露于氟哌利多可使肌肉对催产素敏感。

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