Arnt J, Scheel-Krüger J
Eur J Pharmacol. 1980 Mar 7;62(1):51-61. doi: 10.1016/0014-2999(80)90480-x.
Behavioural effects following bilateral intranigral administration of GABA antagonists have been investigated. Bicuculline methiodide (BMI), picrotoxin and isopropylbicyclophosphate all induced biting behaviour, teeth-chattering and chewing. Sub-threshold doses for biting induced locomotor activity and sniffing. The strongest response was observed after injection into the caudal pars reticulata, whereas weaker effects were seen after injection into the rostral pars reticulata or the pars compacta. The biting induced by intranigral BMI was not antagonized by prior catecholamine depletion with reserpine plus alpha-methyl-p-tyrosine or by dopamine receptor blockade with haloperido. Concomitant intranigral injection of the GABA agonists muscimol and THIP, however, completely antagonized biting. Systemic GABAergic drugs also antagonized the BMI-induced biting: the benzodiazepine, diazepam and the GABA transaminase inhibitor, gamma-acetylenic GABE, were most effective, whereas muscimol was only partially effective and THIP was without effect. It is suggested that this animal model may be used for the evaluation of antidyskinetic drugs.
已经对双侧黑质内注射GABA拮抗剂后的行为效应进行了研究。荷包牡丹碱甲碘化物（BMI）、印防己毒素和异丙基双环磷酸酯均诱发了咬的行为、牙齿打颤和咀嚼。诱发咬的阈下剂量引发了运动活动和嗅探。向尾侧网状部注射后观察到最强反应，而向嘴侧网状部或致密部注射后效应较弱。黑质内注射BMI诱发的咬行为，不会因事先用利血平加α-甲基对酪氨酸使儿茶酚胺耗竭，或用氟哌啶阻断多巴胺受体而受到拮抗。然而，黑质内同时注射GABA激动剂蝇蕈醇和THIP可完全拮抗咬行为。全身性GABA能药物也可拮抗BMI诱发的咬行为：苯二氮䓬类药物地西泮和GABA转氨酶抑制剂γ-乙炔基GABE最有效，而蝇蕈醇仅部分有效，THIP则无效。有人提出，这种动物模型可用于评估抗运动障碍药物。
