Brignole T J, Stott G H
J Dairy Sci. 1980 Mar;63(3):451-6. doi: 10.3168/jds.S0022-0302(80)82952-3.
Dairy claves (983 head) were left with their dams to suckle for 1 day following birth. They then were fed 1 liter of pooled colostrum and placed in individual pens. Blood samples from each calf were taken prior to and 24 h following colostral feeding. Analysis of blood for immunoglobulins G and M indicated that 42% of the calves had failed either to suckle or to absorb colostral immunoglobulins from suckling. Concentrations of IgG and IgM in serum of calves prior to bottle feeding ranged from 0 to 63 mg/ml and 0 to 15 mg/ml with means of 11.3 and 2.9 mg/ml. From bottle feeding 1 liter of colostrum, 70% of the calves absorbed colostral immunoglobulins, an average increase of 5.0 +/- 4.5 mg/ml for IgG and 1.3 +/- 1.3 mg/ml for IgM. Some calves did not absorb IgG from either suckling or bottle feeding (11.9%) and 20.8% failed to absorb IgM. Mortality rate for all experimental calves was 3.9%; for 83 agammaglobulinemic calves, 13.3%. The high rate of survival (86.7%) of the 83 agammaglobulinemic calves could be due to the local prophylactic effect of colostral immunoglobulins in the intestine even though closure had occurred.
乳用犊牛（983头）出生后与它们的母牛一起哺乳1天。然后给它们喂1升混合初乳，并放入单独的围栏中。在初乳喂养前和喂养后24小时采集每头犊牛的血样。对血液中的免疫球蛋白G和M进行分析表明，42%的犊牛要么没有哺乳，要么没有从哺乳中吸收初乳中的免疫球蛋白。奶瓶喂养前犊牛血清中IgG和IgM的浓度范围分别为0至63毫克/毫升和0至15毫克/毫升，平均值分别为11.3和2.9毫克/毫升。通过奶瓶喂养1升初乳，70%的犊牛吸收了初乳中的免疫球蛋白，IgG平均增加5.0±4.5毫克/毫升，IgM平均增加1.3±1.3毫克/毫升。一些犊牛无论是通过哺乳还是奶瓶喂养都没有吸收IgG（11.9%），20.8%的犊牛没有吸收IgM。所有实验犊牛的死亡率为3.9%；83头无丙种球蛋白血症犊牛的死亡率为13.3%。83头无丙种球蛋白血症犊牛的高存活率（86.7%）可能是由于初乳中的免疫球蛋白在肠道中的局部预防作用，尽管肠黏膜已发生封闭。
