Brawer J R, Schipper H, Naftolin F
Endocrinology. 1980 Jul;107(1):274-9. doi: 10.1210/endo-107-1-274.
The effects of estradiol valerate and constant light exposure on the histological appearance of the arcuate nucleus were assessed in female rats. Both of these treatments caused significant increases in the numbers of reactive microglial cells and astrocytic granules in the nucleus. Ovariectomy before either treatment prevented the glial reaction, indicating that the experimental manipulations triggered the secretion of an ovarian product which appears to be selectively toxic to the arcuate nucleus. The fact that monthly injections of estradiol valerate in male rats produced the same profile of degeneration in the arcuate nucleus suggests that the neuropathological agent may itself be estradiol. Ovariectomy also significantly reduced arcuate microglial reactivity associated with normal aging, which suggests that cyclic surges of endogenous estradiol may be capable of gradually producing an arcuate lesion. This phenomenon may accout for the hypothalamic reproductive failure associated with normal aging in the rat.
在雌性大鼠中评估了戊酸雌二醇和持续光照对弓状核组织学外观的影响。这两种处理均导致该核中反应性小胶质细胞和星形胶质细胞颗粒数量显著增加。在任何一种处理之前进行卵巢切除术可防止胶质反应，表明实验操作触发了一种卵巢产物的分泌，该产物似乎对弓状核具有选择性毒性。雄性大鼠每月注射戊酸雌二醇会在弓状核中产生相同的退化情况，这一事实表明神经病理因子本身可能就是雌二醇。卵巢切除术还显著降低了与正常衰老相关的弓状核小胶质细胞反应性，这表明内源性雌二醇的周期性激增可能能够逐渐产生弓状核病变。这种现象可能解释了大鼠正常衰老相关的下丘脑生殖功能衰竭。
