Coulon J, Lematre J, Bonaly R, Pierfitte M
Mycopathologia. 1980 May 1;71(1):17-22. doi: 10.1007/BF00625308.
The antifungal activities of polyen macrolides Amphotericine B and Candicidine are investigated. The deep spectral changes of the absorption and of the circular dichroism show various states of micellar preparations which are: a) in aqueous medium, aggregats of different spectral characteristics, the antifungal activity of which being modulated by the preparation. b) aggregats of antifungal heptaen with membrane-sterol responsable of the antifongal activity. c) aggregats in hydrophobic solutions which spectroscopic properties are sterol-complex like. Our results suggest an explanation of the spectral changes and can point out some favorable characteristics for an optimal activity of these antifungals against yeasts.
研究了多烯大环内酯类药物两性霉素B和杀假丝菌素的抗真菌活性。吸收光谱和圆二色光谱的深度变化显示了胶束制剂的各种状态，这些状态为：a）在水性介质中，具有不同光谱特征的聚集体，其抗真菌活性受制剂调节。b）抗真菌七烯与负责抗真菌活性的膜甾醇形成的聚集体。c）在疏水溶液中的聚集体，其光谱性质类似甾醇复合物。我们的结果对光谱变化做出了解释，并指出了这些抗真菌药物对酵母具有最佳活性的一些有利特征。
