尿素及其衍生物对大鼠慢肌咖啡因挛缩的抑制作用。
Inhibition of caffeine contractures of slow rat muscles by urea and its derivatives.
作者信息
Karpenko D O, Krolenko S A
出版信息
Pflugers Arch. 1980 Mar;384(1):99-101. doi: 10.1007/BF00589521.
PMID:7189873
Abstract
Contractures induced by rapid cooling of rat soleus muscles in the presence of low concentrations of caffeine (2-3 mmol.l-1) have been studied. Urea, methylurea and 1,3-dimethylurea inhibit reversibly these contractures as well as caffeine contractures (20 mmol.l-1, 30 degrees C) but do not affect twitches. This finding leads support to the idea of the existence of different mechanisms activating contraction in response to caffeine action or deplorization.
摘要
在低浓度咖啡因（2 - 3 mmol·l⁻¹）存在的情况下，对大鼠比目鱼肌快速冷却诱导的挛缩进行了研究。尿素、甲基脲和1,3 - 二甲基脲可可逆地抑制这些挛缩以及咖啡因挛缩（20 mmol·l⁻¹，30℃），但不影响抽搐。这一发现支持了存在不同机制来激活因咖啡因作用或去极化而产生的收缩的观点。
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