Miroiu P, Stefăneanu L, Taşcă C
Endocrinologie. 1980 Apr-Jun;18(2):85-9.
The authors studied the 131I thyroid uptake in chronic alcoholism induced in rats (1.5 g alcohol/kg body weight/day) using autohistoradiographic methods. The intensity of 131I uptake was significantly lower in rats which had ingested alcohol: the proportion of follicles with a strong 131I uptake was 5% in alcohol-fed rats as compared to 25% in control rats. The proportion of moderately labeled follicles was decreased too in alcohol-fed rats (34%) as compared to control animals (47%). Concerning the correlation between follicular volume and 131I uptake. It was found that only a reduced percentage (1.8) of follicles with a volume of 50 microm 3 in alcohol-treated rats showed a strong 131I uptake. In the follicles with a volume exceeding 250 microm 3, the uptake was strongly diminished in alcohol-fed animals. In control rats all thyroid follicles showed various percentages of strong 131I uptake. The authors concluded that alcohol might induce a hypothyroidism revealed by 131I uptake diminution.
作者采用自动放射自显影法研究了给大鼠（1.5克酒精/千克体重/天）诱导慢性酒精中毒时的¹³¹I甲状腺摄取情况。摄入酒精的大鼠¹³¹I摄取强度显著降低：摄入酒精的大鼠中¹³¹I摄取强的滤泡比例为5%，而对照大鼠为25%。与对照动物（47%）相比，摄入酒精的大鼠中¹³¹I摄取中度标记的滤泡比例也降低了（34%）。关于滤泡体积与¹³¹I摄取之间的相关性，发现酒精处理的大鼠中体积为50立方微米的滤泡只有减少的比例（1.8%）显示¹³¹I摄取强。在体积超过250立方微米的滤泡中，摄入酒精的动物摄取明显减少。在对照大鼠中，所有甲状腺滤泡都显示出不同比例的¹³¹I摄取强。作者得出结论，酒精可能通过¹³¹I摄取减少诱发甲状腺功能减退。
