Effect of SQ 80,338 (1-(3-phenyl-2-propenyl)-1H-imidazole) on thromboxane synthetase activity and arachidonic acid-induced platelet aggregation and bronchoconstriction. - Suppr | 超能文献

Effect of SQ 80,338 (1-(3-phenyl-2-propenyl)-1H-imidazole) on thromboxane synthetase activity and arachidonic acid-induced platelet aggregation and bronchoconstriction.

作者信息

Harris D N, Greenberg R, Phillips M B, Osman G H, Antonaccio M J

出版信息

Adv Prostaglandin Thromboxane Res. 1980;6:437-41.

Abstract

摘要

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Effect of SQ 80,338 (1-(3-phenyl-2-propenyl)-1H-imidazole) on thromboxane synthetase activity and arachidonic acid-induced platelet aggregation and bronchoconstriction.

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2

Adenylate cyclase activation determines the effect of thromboxane synthase inhibitors on platelet aggregation in vitro. Comparison of platelets from responders and nonresponders.腺苷酸环化酶激活决定了血栓素合酶抑制剂对体外血小板聚集的影响。应答者与无应答者血小板的比较。

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Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase.微克剂量的化合物L8027可抑制花生四烯酸盐介导的支气管收缩和血小板活化，该化合物对血栓素合成酶没有选择性。

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SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor.腺苷酸环化酶抑制剂SQ 22536可阻止血栓素合成酶抑制剂达唑氧苯的抗血小板作用。

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Effect of the thromboxane synthetase inhibitor UK-37,248 (dazoxiben) upon platelet aggregation, coronary artery thrombosis and vascular reactivity.血栓素合成酶抑制剂UK-37,248（达唑氧苯）对血小板聚集、冠状动脉血栓形成及血管反应性的影响。

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Effects of Y-20811, a long-lasting thromboxane synthetase inhibitor, on thromboxane production and platelet function.长效血栓素合成酶抑制剂Y-20811对血栓素生成及血小板功能的影响。

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Effects of a thromboxane synthetase inhibitor and a cAMP phosphodiesterase inhibitor, singly and in combination, on platelet behaviour.血栓素合成酶抑制剂和环磷酸腺苷磷酸二酯酶抑制剂单独及联合应用对血小板行为的影响。

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Lag-phase of arachidonic acid-induced secretion in responders and non-responders to the thromboxane-synthetase inhibitors: involvement of cyclic-AMP.对血栓素合成酶抑制剂有反应者和无反应者中花生四烯酸诱导分泌的延迟期：环磷酸腺苷的作用。

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Naunyn Schmiedebergs Arch Pharmacol. 1984 Sep;327(2):148-55. doi: 10.1007/BF00500910.

2

The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs.白三烯拮抗剂、脂氧合酶抑制剂及选定标准品对豚鼠白三烯介导的过敏性支气管痉挛的作用。

Agents Actions. 1989 Nov;28(3-4):173-84. doi: 10.1007/BF01967398.