相似文献

1

Interaction of human serum albumin with anticancer agents in vitro.

Br J Cancer. 1980 Apr;41(4):602-8. doi: 10.1038/bjc.1980.103.

2

The effects of ICRF-154 in combination with other anticancer agents in vitro.

Br J Cancer. 1992 Aug;66(2):281-6. doi: 10.1038/bjc.1992.257.

3

Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro.

Anticancer Res. 1990 Nov-Dec;10(6):1643-5.

4

Effect of L-phenylalanine mustard, adriamycin, actinomycin D, and 4'-(9-acridinylamino)methanesulfon-m-anisidide on naturally occurring human spontaneous monocyte-mediated cytotoxicity.

Cancer Res. 1982 May;42(5):1692-5.

5

[Potentiation of the cytotoxic effects of various anticancer drugs by interferon on human neoplastic cells (HeLa) in culture].

Gan To Kagaku Ryoho. 1983 May;10(5):1308-12.

6

Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols.

Gan. 1983 Oct;74(5):759-66.

7

Anticancer drugs: effect on the cloning of Raji lymphoma cells in soft agar.

J Natl Cancer Inst. 1982 Jan;68(1):115-21.

8

Interaction of albumin and vincristine with a human lymphoblastic leukemia cell line in vitro.

Cancer Biochem Biophys. 1980;4(3):133-6.

9

Synergistic cytotoxicity of recombinant human TNF and various anti-cancer drugs.

Immunopharmacol Immunotoxicol. 1988;10(1):117-27. doi: 10.3109/08923978809014406.

10

Synergistic cell killing by antitumor agents and hyperthermia in cultured cells.

Gan. 1980 Aug;71(4):471-8.

引用本文的文献

1

Targeted Treatment of Sarcomas by Single Protein Encapsulated Doxorubicin with Undetectable Cardiotoxicity and Superior Efficacy.

Cancers (Basel). 2025 Mar 4;17(5):881. doi: 10.3390/cancers17050881.

2

Covalent and non-covalent albumin binding of Au(i) bis-NHCs post-synthetic amide modification.

Chem Sci. 2021 Apr 26;12(21):7547-7553. doi: 10.1039/d1sc01055g.

3

Weakening Impact of Excessive Human Serum Albumin (eHSA) on Cisplatin and Etoposide Anticancer Effect in C57BL/6 Mice with Tumor and in Human NSCLC A549 Cells.

Front Pharmacol. 2016 Nov 15;7:434. doi: 10.3389/fphar.2016.00434. eCollection 2016.

4

Protein binding of anthraquinone glycosides, with special reference to adriamycin.

Cancer Chemother Pharmacol. 1982 Dec;10(1):7-10. doi: 10.1007/BF00257228.

5

Differential serum protein binding of benzidine- and benzidine-congener based dyes and their derivatives.

Arch Toxicol. 1985 Jun;57(2):130-5. doi: 10.1007/BF00343123.

6

Cytotoxicity and metabolism of prednimustine, chlorambucil and prednisolone in a Chinese hamster cell line.

Cancer Chemother Pharmacol. 1986;16(2):85-90. doi: 10.1007/BF00256154.

7

Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. General considerations, the nitrosoureas and alkylating agents.

Cancer Chemother Pharmacol. 1985;14(2):83-95. doi: 10.1007/BF00434343.

8

Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. III. Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumor agents.

Cancer Chemother Pharmacol. 1989;23(4):197-207. doi: 10.1007/BF00451642.

9

Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. II. Assay methods, adriamycin and the other antitumour antibiotics.

Cancer Chemother Pharmacol. 1986;17(1):1-10. doi: 10.1007/BF00299858.

本文引用的文献

1

Some interactions of nitrogen mustards with constituents of human blood serum.

Biochem Pharmacol. 1961 Dec;8:343-57. doi: 10.1016/0006-2952(61)90051-x.

2

Tumor and marrow damage occurring from methotrexate, monofluoromethotrexate, difluoromethotrexate, and dichloromethotrexate.

Cancer Res. 1961 Jul;21:743-8.

3

Comparison of the relative effectiveness of folic acid congeners against advanced leukemia in mice.

J Natl Cancer Inst. 1957 Dec;19(6):1133-5.

4

Antitumor activity and pharmacologic disposition of cytosine arabinoside (NSC-63878).

Cancer Chemother Rep. 1965 Oct;48:11-6.

5

Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes.

J Natl Cancer Inst. 1972 Sep;49(3):891-5.

6

Clinical and pharmacological studies with cis-diamminedichloroplatinum (II).

Cancer Res. 1973 Jun;33(6):1310-5.

7

Interaction of vinblastine, vincristine and colchicine with serum proteins.

Biochem Pharmacol. 1973 Sep 1;22(17):2113-9. doi: 10.1016/0006-2952(73)90110-x.

8

Binding of drugs to serum albumin (first of two parts).

N Engl J Med. 1976 Feb 5;294(6):311-6. doi: 10.1056/NEJM197602052940605.

9

Pharmacokinetic study of cis-dichlorodiammineplatinum(II) (DDP) in the beagle dog: thermodynamic and kinetic behavior of DDP in a biologic millieu.

Cancer Treat Rep. 1979 Jan;63(1):59-71.

10

A comparison of the biological effects of dichloromethotrexate and methotrexate on human leukemic cells in culture.

Cancer Res. 1979 Apr;39(4):1264-8.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

人血清白蛋白与抗癌药物的体外相互作用。

Interaction of human serum albumin with anticancer agents in vitro.

作者信息

Takahashi I, Ohnuma T, Kavy S, Bhardwaj S, Holland J F

出版信息

Br J Cancer. 1980 Apr;41(4):602-8. doi: 10.1038/bjc.1980.103.

DOI:10.1038/bjc.1980.103

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2010273/

Abstract

The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diamminedichloroplatinum (II), 4'-(9-acridinylamino)methanesulphon-m-anisidide, neocarzinostatin, nitrogen mustard, adriamycin, daunorubicin and mitomycin C--drugs whose biological activities are reduced in the presence of HA. The biological activities of Type II drugs (cytosine arabinoside, fluorouracil and actinomycin D) are not influenced by HA. The biological activities of Type III drugs (bleomycin, vincristine and vinblastine) are increased in the presence of HA. These results indicate that serum HA interferes in vitro with certain anticancer agents in terms of biological activity and, probably, clinical effectiveness. HA-drug interaction may be a major factor governing the pharmacology of Type I anticancer agents in man.

摘要

在人白血病细胞系MOLT-3中对人血清白蛋白（HA）对13种化疗药物生物学效应的影响进行了体外研究。根据HA影响的生物学活性变化，这些药物可分为三类。I类药物包括顺二氨二氯铂（II）、4'-（9-吖啶基氨基）甲磺基间茴香胺、新制癌菌素、氮芥、阿霉素、柔红霉素和丝裂霉素C，这些药物在有HA存在时生物学活性降低。II类药物（阿糖胞苷、氟尿嘧啶和放线菌素D）的生物学活性不受HA影响。III类药物（博来霉素、长春新碱和长春花碱）在有HA存在时生物学活性增强。这些结果表明，血清HA在体外就生物学活性以及可能的临床疗效方面干扰某些抗癌药物。HA与药物的相互作用可能是决定I类抗癌药物在人体内药理学特性的一个主要因素。