Beaubernard C, Salomon F, Bismuth H
Biomedicine. 1980 May;32(2):76-80.
The organization of the diurnal sleep pattern was studied in control rats and in rats with end-to-side portocaval shunt before operation and during five weeks after operation. In control rats, no modification of the states of sleep was observed during the experimentation. In shunted rats, the total duration of waking increased, the total duration of slow wave sleep and paradoxical sleep decreased. The number of phases of waking and slow wave sleep increased and the number of phases of paradoxical sleep decreased. The mean duration of the phases of slow wave sleep decreased. These results show that the electrophysiological expression of experimental hepatic encephalopathy is similar to the electroclinical expression of hepatic encephalopathy in man and the polygraphic study of sleep disturbances permits the description of the encephalopathies.
在对照组大鼠以及接受端侧门腔分流术的大鼠术前及术后五周内，对其昼夜睡眠模式的组织情况进行了研究。在对照组大鼠中，实验期间未观察到睡眠状态的改变。在接受分流术的大鼠中，清醒总时长增加，慢波睡眠和异相睡眠的总时长减少。清醒和慢波睡眠的阶段数增加，而异相睡眠的阶段数减少。慢波睡眠阶段的平均时长减少。这些结果表明，实验性肝性脑病的电生理表现与人类肝性脑病的电临床表现相似，并且睡眠障碍的多导睡眠图研究有助于描述脑病情况。
