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实验性肝性脑病。门腔分流大鼠清醒水平的变化。

Experimental hepatic encephalopathy. Changes of the level of wakefulness in the rat with portacaval shunt.

作者信息

Beaubernard C, Salomon F, Grange D, Thangapregassam M J, Bisbuth J

出版信息

Biomedicine. 1977 Jun;27(4):169-71.

PMID:890024
Abstract

The level of wakefulness in rats with portacaval shunt has been evaluated by measurement of the reactivity of the reticulocortical system by electric stimulation of the brain stem reticular formation during slow wave sleep. The voltage level of stimulus necessary to provoke cortical awakening is significantly decreased after portacaval shunt. This modification of the level of wakefulness is in accordance with the diminution of total sleep and the decrease in threshold of reaction to painful stimuli observed in rats after portacaval shunt. The measurement of the reactivity of the reticulocortical system is a simple procedure which permits quantification of post-shunt encephalopathy in the rat.

摘要

通过在慢波睡眠期间电刺激脑干网状结构来测量大鼠网状皮质系统的反应性，对门腔分流大鼠的觉醒水平进行了评估。门腔分流后，引发皮质觉醒所需的刺激电压水平显著降低。觉醒水平的这种改变与门腔分流大鼠观察到的总睡眠时间减少以及对疼痛刺激的反应阈值降低相一致。网状皮质系统反应性的测量是一种简单的程序，可对大鼠分流后脑病进行量化。

相似文献

1
Experimental hepatic encephalopathy. Changes of the level of wakefulness in the rat with portacaval shunt.实验性肝性脑病。门腔分流大鼠清醒水平的变化。
Biomedicine. 1977 Jun;27(4):169-71.
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[Experimental hepatic encephalopathy. Study of the organization of a diurnal sleep pattern in rats with portocaval anastomosis].[实验性肝性脑病。门腔静脉吻合大鼠昼夜睡眠模式的组织研究]
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[Experimental hepatic encephalopathy. Central nervous system excitability in rats following portacaval anastomosis].[实验性肝性脑病。门腔静脉吻合术后大鼠的中枢神经系统兴奋性]
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Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis.门腔静脉吻合大鼠的皮质-纹状体突触可塑性和行为习惯化缺陷。
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[Experimental hepatic encaphalopathy. I. Changes in the pattern of sleep following portacaval shunt in the rat (author's transl)].[实验性肝性脑病。I. 大鼠门腔静脉分流术后睡眠模式的变化（作者译）]
Biol Gastroenterol (Paris). 1976 Apr-May;9(2):99-103.
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[Experimental hepatic encephalopathy. Study of nycthemeral organization of waking-sleep cycle in the rat with portacaval shunt (author's transl)].[实验性肝性脑病。门腔分流大鼠昼夜清醒-睡眠周期的组织学研究（作者译）]
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[Experimental hepatic encephaloapthy. II. Study of the response to nociceptive stimuli in the rat following portacaval shunt (author's transl)].[实验性肝性脑病。II. 门腔静脉分流术后大鼠对伤害性刺激反应的研究（作者译）]
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