章鱼唾腺精氨酸加压素C末端六肽酰胺的一些类似物的合成及其降压活性
Synthesis and hypotensive activity of some analogs of the C-terminal hexapeptideamide of eledoisin.
作者信息
von Dungen A, Hoefke W
出版信息
Arzneimittelforschung. 1980;30(4):589-91. doi: 10.1002/chin.198031306.
PMID:7190397
Abstract
The C-terminal (6-11)-hexapeptideamide Ala-Phe-Ile-Gly-Leu-Met-NH2 of eledoisin was synthesized by the solid phase method according to Merrifield. The alpha-amino group of alanine was acylated with heterocyclic or aromatic residues. These new compounds showed dose dependent hypotensive activities in the rabbit.
摘要
根据梅里菲尔德的方法，通过固相法合成了eledoisin的C末端（6-11）-六肽酰胺Ala-Phe-Ile-Gly-Leu-Met-NH2。丙氨酸的α-氨基用杂环或芳族残基进行酰化。这些新化合物在兔中显示出剂量依赖性的降压活性。
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