核甘露糖基转移酶的研究：脂质中间体
Study of nuclear mannosyl-transferase: lipids intermediates.
作者信息
Richard M, Tytgat F, Louisot P
出版信息
Biochimie. 1978 Sep 29;60(6-7):593-9. doi: 10.1016/s0300-9084(78)80777-9.
PMID:719042
Abstract
Mannosyl-transferase of rat liver nuclei catalyzed the transfer of mannose, from GDP-mannose, to endogeneous lipids and proteins. Two solubility-different glycolipids were characterized: a mannosyl-phosphoryl-dolichol and an oligosaccharide-lipid. The labeling of the two lipids was consistent with a role in mannose transfer to nuclear glycoproteins, but not according to the Lennarz' scheme.
摘要
大鼠肝细胞核的甘露糖基转移酶催化甘露糖从GDP-甘露糖转移至内源性脂质和蛋白质。鉴定出两种溶解度不同的糖脂：一种甘露糖基磷酸化多萜醇和一种寡糖脂质。这两种脂质的标记结果与在甘露糖向核糖蛋白转移过程中的作用一致，但不符合伦纳兹的方案。
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