Mathew O P, Bland H, Boxerman S B, James E
Pediatrics. 1980 Aug;66(2):224-7.
Determination of CSF lactate levels were performed in 150 nonasphyxiated and 46 asphyxiated high risk neonates. Statistical analysis of log lactate levels of nonasphyxiated infants showed significant relationship to gestational and postnatal ages (P < .0001 and < .0002, respectively). CSF lactate elevation was seen in 16/29 infants studied within eight hours of asphyxia in contrast to 0/17 infants studied after eight hours (P < .001). Higher incidence of CSF lactate elevation was seen in term infants (7/8), infants with fetal distress (13/17), and very low Apgar scores (11/18). Seven of eight infants with markedly elevated lactate levels had both fetal distress and very low Apgar scores. CSF lactate determination in the immediate postasphyxial period appears to be an objective way of assessing the severity of cerebral hypoxia.
对150名非窒息高危新生儿和46名窒息高危新生儿进行了脑脊液乳酸水平测定。对非窒息婴儿的对数乳酸水平进行统计分析，结果显示其与胎龄和出生后年龄有显著关系（分别为P <.0001和<.0002）。在窒息后8小时内研究的29名婴儿中有16名出现脑脊液乳酸升高，而在8小时后研究的17名婴儿中则无此现象（P <.001）。足月儿（7/8）、有胎儿窘迫的婴儿（13/17）和阿氏评分极低的婴儿（11/18）中脑脊液乳酸升高的发生率较高。乳酸水平明显升高的8名婴儿中有7名同时患有胎儿窘迫和阿氏评分极低。窒息后即刻进行脑脊液乳酸测定似乎是评估脑缺氧严重程度的一种客观方法。
