脑脊液中次黄嘌呤、黄嘌呤、尿苷和肌苷的浓度：缺氧后ATP代谢产物次黄嘌呤的高浓度。
Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and inosine: high concentrations of the ATP metabolite, hypoxanthine, after hypoxia.
作者信息
Harkness R A, Lund R J
出版信息
J Clin Pathol. 1983 Jan;36(1):1-8. doi: 10.1136/jcp.36.1.1.
Abstract
CSF obtained for clinical purposes from newborn, children and adults has been analysed by high pressure liquid chromatography for hypoxanthine, xanthine, inosine, uridine and urate. Large rises in hypoxanthine and to a lesser extent xanthine occur for about 24 h after hypoxia. High concentrations were associated with later evidence of brain damage or subsequent death. Changes in CSF could be independent of those in plasma. Small or negligible rises were associated with localised and generalised infections including bacterial meningitis, fits, or both. Marked and rapid rises were found after death. These estimations may "predict" the extent of brain damage or brain death.
摘要
为临床目的从新生儿、儿童和成人获取的脑脊液，已通过高压液相色谱法分析其中的次黄嘌呤、黄嘌呤、肌苷、尿苷和尿酸盐。缺氧后约24小时，次黄嘌呤大幅升高，黄嘌呤升高幅度较小。高浓度与随后出现的脑损伤证据或死亡相关。脑脊液的变化可能与血浆变化无关。小幅度升高或可忽略不计的升高与局部和全身性感染有关，包括细菌性脑膜炎、惊厥或两者皆有。死后发现有明显且快速的升高。这些测定可能“预测”脑损伤或脑死亡的程度。
相似文献
1
Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and inosine: high concentrations of the ATP metabolite, hypoxanthine, after hypoxia.脑脊液中次黄嘌呤、黄嘌呤、尿苷和肌苷的浓度：缺氧后ATP代谢产物次黄嘌呤的高浓度。
J Clin Pathol. 1983 Jan;36(1):1-8. doi: 10.1136/jcp.36.1.1.
2
Adenosine, inosine, hypoxanthine, xanthine and uric acid concentrations in the cerebrospinal fluid of unanaesthetized rats.未麻醉大鼠脑脊液中腺苷、肌苷、次黄嘌呤、黄嘌呤和尿酸的浓度
J Pharm Pharmacol. 1989 Mar;41(3):216. doi: 10.1111/j.2042-7158.1989.tb06437.x.
3
The measurement of hypoxanthine, xanthine, inosine and uridine in umbilical cord blood and fetal scalp blood samples as a measure of fetal hypoxia.测量脐带血和胎儿头皮血样本中的次黄嘌呤、黄嘌呤、肌苷和尿苷，以此作为胎儿缺氧的一项指标。
Br J Obstet Gynaecol. 1981 Apr;88(4):381-90. doi: 10.1111/j.1471-0528.1981.tb01001.x.
4
Concentration of purine compounds in the cerebrospinal fluid of infants suffering from sepsis, convulsions and hydrocephalus.患有败血症、惊厥和脑积水的婴儿脑脊液中嘌呤化合物的浓度。
J Perinat Med. 1995;23(3):167-74. doi: 10.1515/jpme.1995.23.3.167.
5
Concentrations of nucleotides, nucleosides, purine bases and urate in cerebrospinal fluid of children with meningitis.患脑膜炎儿童脑脊液中核苷酸、核苷、嘌呤碱和尿酸盐的浓度。
Acta Paediatr. 1993 Oct;82(10):849-52. doi: 10.1111/j.1651-2227.1993.tb17625.x.
6
Alterations in cerebrospinal fluid uridine, hypoxanthine, and xanthine in head-injured patients.头部受伤患者脑脊液中尿苷、次黄嘌呤和黄嘌呤的变化。
Cell Mol Neurobiol. 1988 Jun;8(2):235-43. doi: 10.1007/BF00711249.
7
Avian vitreous humor concentrations of inosine, hypoxanthine, xanthine, uric acid, uracil and uridine as influenced by age and sex: their relevance as indicators of ante-mortem hypoxia.年龄和性别对鸟类玻璃体液中肌苷、次黄嘌呤、黄嘌呤、尿酸、尿嘧啶和尿苷浓度的影响：它们作为生前缺氧指标的相关性。
Forensic Sci Int. 1990 Sep;47(2):123-7. doi: 10.1016/0379-0738(90)90206-e.
8
Hypoxanthine, xanthine, urate and creatinine concentration gradients in cerebrospinal fluid.脑脊液中次黄嘌呤、黄嘌呤、尿酸盐和肌酐的浓度梯度
Ups J Med Sci. 1988;93(3):225-32. doi: 10.3109/03009738809178548.
9
Determination of rat cerebrospinal fluid concentrations of adenosine, inosine, hypoxanthine, xanthine and uric acid by high performance liquid chromatography.用高效液相色谱法测定大鼠脑脊液中腺苷、肌苷、次黄嘌呤、黄嘌呤和尿酸的浓度。
J Pharm Pharmacol. 1988 Feb;40(2):140-2. doi: 10.1111/j.2042-7158.1988.tb05201.x.
10
Cerebrospinal fluid nucleotide metabolites following non-convulsive status epilepticus.非惊厥性癫痫持续状态后的脑脊液核苷酸代谢产物
Dev Med Child Neurol. 1989 Apr;31(2):168-73. doi: 10.1111/j.1469-8749.1989.tb03975.x.
引用本文的文献
1
The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development.嘌呤代谢和尿酸在出生后神经发育中的作用。
Molecules. 2025 Feb 11;30(4):839. doi: 10.3390/molecules30040839.
2
Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides.使用嘌呤核苷的新生儿脑病即时诊断新方法
Front Mol Neurosci. 2021 Sep 9;14:732199. doi: 10.3389/fnmol.2021.732199. eCollection 2021.
3
Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease.先天性心脏病新生儿和婴儿低氧血症相关代谢物的改变。
Congenit Heart Dis. 2020 Sep 7;15(4):251-265. doi: 10.32604/chd.2020.012219.
4
Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP.细胞内三磷酸腺苷（ATP）短缺作为疾病病因及增强ATP的策略
Front Pharmacol. 2019 Feb 19;10:98. doi: 10.3389/fphar.2019.00098. eCollection 2019.
5
Impact of euthanasia, dissection and postmortem delay on metabolic profile in mouse retina and RPE/choroid.安乐死、解剖和死后延迟对小鼠视网膜和 RPE/脉络膜代谢谱的影响。
Exp Eye Res. 2018 Sep;174:113-120. doi: 10.1016/j.exer.2018.05.032. Epub 2018 Jun 1.
6
Biochemical measurement of neonatal hypoxia.新生儿缺氧的生化检测
J Vis Exp. 2011 Aug 24(54):2948. doi: 10.3791/2948.
7
Cerebrospinal fluid purine metabolites after complex febrile convulsions.复杂性热性惊厥后的脑脊液嘌呤代谢产物
Childs Nerv Syst. 1996 Jun;12(6):315-7. doi: 10.1007/BF00301019.
8
Cerebrospinal fluid amino acids, purines and pyrimidines as a tool in the study of metabolic brain diseases.脑脊液中的氨基酸、嘌呤和嘧啶作为研究脑部代谢疾病的一种工具。
J Inherit Metab Dis. 1993;16(4):670-5. doi: 10.1007/BF00711899.
9
Introduction to the age-related diagnosis (ARD) index: an age at presentation related index for diagnostic use.年龄相关诊断（ARD）指数简介：一种用于诊断的就诊年龄相关指数。
J Inherit Metab Dis. 1993;16(2):161-70. doi: 10.1007/BF00710248.
10
Indicators of hypoxia in cerebrospinal fluid of hydrocephalic children with suspected shunt malfunction.疑似分流功能障碍的脑积水患儿脑脊液中的缺氧指标
Childs Nerv Syst. 1993 Aug;9(5):275-7. doi: 10.1007/BF00306272.
本文引用的文献
1
High-performance liquid chromatographic methods for base and nucleoside analysis in extracellular fluids and in cells.用于细胞外液和细胞中碱基与核苷分析的高效液相色谱法。
J Chromatogr. 1981 Dec 11;226(2):369-81. doi: 10.1016/s0378-4347(00)86071-5.
2
Effect of renal failure on erythrocyte purine nucleotide, nucleoside and base concentrations and some related enzyme activities.肾衰竭对红细胞嘌呤核苷酸、核苷和碱基浓度以及一些相关酶活性的影响。
Clin Sci (Lond). 1981 Dec;61(6):757-64. doi: 10.1042/cs0610757.
3
The measurement of hypoxanthine, xanthine, inosine and uridine in umbilical cord blood and fetal scalp blood samples as a measure of fetal hypoxia.测量脐带血和胎儿头皮血样本中的次黄嘌呤、黄嘌呤、肌苷和尿苷，以此作为胎儿缺氧的一项指标。
Br J Obstet Gynaecol. 1981 Apr;88(4):381-90. doi: 10.1111/j.1471-0528.1981.tb01001.x.
4
CSF lactate levels in high risk neonates with and without asphyxia.有窒息和无窒息高危新生儿的脑脊液乳酸水平
Pediatrics. 1980 Aug;66(2):224-7.
5
Cot deaths in Edinburgh: infant feeding and socioeconomic factors.爱丁堡的婴儿猝死：婴儿喂养及社会经济因素
J Epidemiol Community Health. 1980 Mar;34(1):35-41. doi: 10.1136/jech.34.1.35.
6
Nucleotide, nucleoside and purine base concentrations in human placentae.人胎盘组织中的核苷酸、核苷及嘌呤碱浓度
Placenta. 1982 Jan-Mar;3(1):29-38. doi: 10.1016/s0143-4004(82)80015-5.
7
Energy metabolism and cellular pH in normal and pathological conditions. A new look through 31phosphorus nuclear magnetic resonance.正常和病理状态下的能量代谢与细胞pH值。通过31磷核磁共振的新视角。
Ciba Found Symp. 1982;87:36-57. doi: 10.1002/9780470720691.ch3.
8
Intrapartum hypoxia: the association between neurological assessment of damage and abnormal excretion of ATP metabolites.产时缺氧：损伤的神经学评估与ATP代谢产物异常排泄之间的关联
J Clin Pathol. 1982 Sep;35(9):999-1007. doi: 10.1136/jcp.35.9.999.
9
Birth asphyxia.出生窒息
Br Med J (Clin Res Ed). 1982 May 1;284(6325):1288-9. doi: 10.1136/bmj.284.6325.1288.
10
Biogenesis of mitochondria. 8. The effect of chloramphenicol on regenerating rat liver.线粒体的生物发生。8. 氯霉素对再生大鼠肝脏的影响。
Exp Cell Res. 1969 Apr;55(1):68-76. doi: 10.1016/0014-4827(69)90457-1.
Zotero 插件