Horácek J, Uhde W J
J Hyg Epidemiol Microbiol Immunol. 1980;24(2):133-41.
In model elution tests migration of 2-hydroxy-3-n-octyloxybenzophenome and its isooctyl derivative from polystyrene and polyolefines and 3,5ditert. butyl 4-hydroxy-[2,4-ditert, butylphenyl]-benzoate from polypropylene always at two concentration levels was investigated. For determination photometric measurements in the ultraviolet zone of the spectrum after a previous separation by thin layer chromatography and gas chromatography was used. A very low elution of the studied substances into water and aqueous acid solutions simulated by a solution of acetic acid was found. Migration of the evaluated compounds into 50% alcohol attains---depending on the conditions of the experiment---values in the order of milligrammes per one square dm of the surface of the plastic and is, moreover, 3 to 20 times higher in case of contact with fats or fat-simulating liquids. On the basis of the obtained results and after summarization of the toxicological data it was recommended to adopt a positive standpoint to all the compounds with a restriction of their amount in plastics except for the use of plastics containing these additives which come into contact with fats or fat containing food.
在模型洗脱试验中,研究了2-羟基-3-正辛氧基二苯甲酮及其异辛酯从聚苯乙烯和聚烯烃中的迁移情况,以及3,5-二叔丁基-4-羟基-[2,4-二叔丁基苯基]-苯甲酸酯从聚丙烯中的迁移情况,浓度均为两个水平。测定时,先通过薄层色谱和气相色谱进行分离,然后在光谱的紫外区进行光度测量。结果发现,所研究的物质在水中以及由醋酸溶液模拟的酸性水溶液中的洗脱率非常低。评估的化合物向50%酒精中的迁移量——取决于实验条件——每平方分米塑料表面可达毫克级,此外,与脂肪或脂肪模拟液体接触时,迁移量要高出3至20倍。根据所获结果并汇总毒理学数据后,建议对所有化合物持肯定态度,但要限制其在塑料中的含量,除非使用含有这些添加剂且与脂肪或含脂肪食品接触的塑料。