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华法林处理后TMB(特赖恩迷宫聪慧型)和TMD(特赖恩迷宫迟钝型)大鼠的血小板计数(作者译)

[Thrombocyte counts in TMB (Tryon Maze Brights) and TMD (Tryon Maze Dulls) rats following warfarin (author's transl)].

作者信息

Freund J L, Gutmark J, Freund D, Kahlau F, Glanzmann P

出版信息

Arzneimittelforschung. 1980;30(6):954-5.

PMID:7191271
Abstract

A dosage of 3 mg Warfarin/kg body weight causes a highly significant increase in the number of platelets both in TMB (Tryon maze brights) and TMD (Tryon maze dulls) rats. Different "intelligence levels" show no effect on this increase. In condition of rest the number of platelets is significantly higher in TMD rats than in TMB animals. With regard to a hypothetical relationship between the number of platelets and the amount of circulating and urinary catecholamines the results suggest a similar relationship in conditions of rest as can be shown in emotive (e+) and nonemotive (e--) Wistar rats as well as a varying reaction to stress -- different levels of "intelligence" and anxiety provided.

摘要

每千克体重3毫克华法林的剂量会使TMB(特赖恩迷宫聪明鼠)和TMD(特赖恩迷宫迟钝鼠)大鼠的血小板数量显著增加。不同的“智力水平”对此增加没有影响。在休息状态下,TMD大鼠的血小板数量显著高于TMB大鼠。关于血小板数量与循环及尿中儿茶酚胺量之间的假设关系,结果表明在休息状态下存在与动情(e+)和不动情(e--)的Wistar大鼠相似的关系,以及对应激的不同反应——前提是存在不同水平的“智力”和焦虑。

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