Hulhoven R
Biomedicine. 1978 Jul;29(5):164-7.
The pharmacokinetics of daunorubicin and daunorubin-DNA complex were studied in the rabbit after i.v. bolus injection and a 4hr infusion period. The plasma levels of daunorubicin and daunorubicinol were measured by high-pressure liquid chromatography and the DNA plasma levels by means of 125I labelled DNA. The results demonstrated a slower distribution of the complex; however, the more rapid decrease in the plasma levels of daunorubicin than that of DNA suggested that this complex essentially constitutes a "daunorubicin circulating pool" from which the drug diffuses more slowly than after the administration of uncomplexed daunorubicin.
在兔静脉推注及4小时输注后，研究了柔红霉素及柔红霉素 - DNA复合物的药代动力学。通过高压液相色谱法测定柔红霉素和柔红霉素醇的血浆水平，借助125I标记的DNA测定血浆中DNA水平。结果表明复合物的分布较慢；然而，柔红霉素血浆水平的下降比DNA更快，这表明该复合物本质上构成了一个“柔红霉素循环池”，与未复合的柔红霉素给药后相比，药物从该循环池中扩散得更慢。
