Harada K, Suzuki S, Ishida H
Biosystems. 1978 Aug;10(3):247-51. doi: 10.1016/0303-2647(78)90006-0.
Contact glow discharge electrolyses (CGDE) were carried out relative to the prebiotic formation of amino acids by amination of aliphatic nitrile in aqueous ammoniacal solution, and by cyanization of aliphatic amine by sodium cyanide. The CGDE of propionitrile by amination followed by hydrolysis resulted in the formation of glycine, alanine and beta-alanine. The reaction of ethylamine by cyanization, gave glycine, alanine, beta-alanine, aspartic acid, and serine. In these reactions, a relatively high ratio of glycine was observed. This could be explained by the cleavage of the alpha,beta-carbon bond, which was broken easily, due to the strong electron-attracting property of the nitrile group of propionitrile and the resulting alpha-aminopropionitrile.
进行了接触辉光放电电解（CGDE），以研究在氨水溶液中通过脂肪族腈的胺化作用以及通过氰化钠对脂肪族胺进行氰化作用来实现氨基酸的益生元形成。丙腈通过胺化然后水解的接触辉光放电电解产生了甘氨酸、丙氨酸和β-丙氨酸。乙胺通过氰化反应生成了甘氨酸、丙氨酸、β-丙氨酸、天冬氨酸和丝氨酸。在这些反应中，观察到甘氨酸的比例相对较高。这可以通过α,β-碳键的断裂来解释，由于丙腈的腈基具有很强的吸电子特性以及由此产生的α-氨基丙腈，该碳键很容易断裂。
