Kaledin V I, Gruntenko E V, Morozkova T S
Biull Eksp Biol Med. 1978 Nov;86(11):574-6.
Lung adenomas arose in 2 of 10 nude mice injected twice with urethane in a dose of 1 mg/g of body weight; these tumours were revealed in 7 of 10 immunologically normal littermates treated in the same way. Mean adenoma numbers were 0.2 +/- 0.13 per nude mouse and 1.2 +/- 0.36 per normal mouse (P less than 0.05). The data obtained do not agree with the immunological surveillance concept which predicts greated number of tumours in the nude mice in comparison with the normal ones.
给10只裸鼠按1毫克/克体重的剂量注射两次氨基甲酸乙酯，其中2只出现了肺腺瘤；对10只以同样方式处理的免疫正常同窝小鼠进行检查，发现其中7只出现了这些肿瘤。每只裸鼠的平均腺瘤数量为0.2±0.13个，每只正常小鼠为1.2±0.36个（P<0.05）。所获得的数据与免疫监视概念不符，该概念预测裸鼠中的肿瘤数量会比正常小鼠更多。
