Sillau A H, Cueva S, Morales P
Pflugers Arch. 1980 Aug;386(3):269-75. doi: 10.1007/BF00587478.
Two-hundred one-dayy-old male (M) and female (F) chickens were exposed to 3300 m (HA). Two-hundred control chickens were raised at sea level (SL). Chickens from both HA and SL were studied each week from the 3rd to the 7th week of age. Pulmonary arterial pressure (Ppa) was measured under local anesthesia in conscious animals. Hb, Hct and red blood cell counts (E) and the weights of the right ventricle (RV), left ventricle (LV) and septum (S) were obtained. HA chickens, both males and females, reached lower body weights than SL chickens. Ppa were 16 and 43 mm Hg (2.13 and 5.73 kPa) while RV/(RV + LV + S) values were 0.195 and 0.347 in SL and HA chickens, respectively. RV was 90% greater and LV 20% smaller in the HA chickens. S was not affected by altitude. Hb, Hct and E were higher in the HA birds. Sixteen HA M and 1 HA F died with signs of right heart insufficiency (RHI), however, M did not show greater values of Ppa or RV/(RV + LV + S) than F at SL or at HA. This indicates that the higher incidence of RHI in the M cannot be attributed to a higher responsiveness of their pulmonary vasculature to hypoxia.
201只1日龄雄性（M）和雌性（F）鸡被置于海拔3300米（HA）处。200只对照鸡在海平面（SL）饲养。从3周龄到7周龄，每周对HA组和SL组的鸡进行研究。在局部麻醉下对清醒动物测量肺动脉压（Ppa）。获取血红蛋白（Hb）、血细胞比容（Hct）、红细胞计数（E）以及右心室（RV）、左心室（LV）和室间隔（S）的重量。HA组的雄性和雌性鸡体重均低于SL组鸡。SL组和HA组鸡的Ppa分别为16和43毫米汞柱（2.13和5.73千帕），而RV/（RV + LV + S）值分别为0.195和0.347。HA组鸡的RV大90%，LV小20%。S不受海拔影响。HA组鸡的Hb、Hct和E较高。16只HA组雄性鸡和1只HA组雌性鸡死于右心衰竭（RHI）体征，然而，在SL组或HA组，雄性鸡的Ppa或RV/（RV + LV + S）值并不高于雌性鸡。这表明雄性鸡中RHI发病率较高不能归因于其肺血管对缺氧的更高反应性。
