Picozzi V J, Roeske W R, Creger W P
Am J Med. 1980 Nov;69(5):690-4. doi: 10.1016/0002-9343(80)90419-2.
Of 38 adult patients with idiopathic thrombocytopenic purpura followed an average of more than 12 years, 15 suffered splenectomy failure or postsplenectomy recurrence of thrombocytopenia. Nine of the 15 also received immunosuppressive agents, and four of the nine failed such therapy. In eight of these 15 treatment failures normal or safe platelet counts were achieved in a subsequent three to 12 year period during which they received no therapy. The frequency of spontaneous recovery of satisfactory platelet levels in adults with idiopathic thrombocytopenic purpura in whom treatment failed may have negative implications for very vigorous or longstanding immunosuppressive therapeutic attempts in certain cases.
在38例平均随访超过12年的成人特发性血小板减少性紫癜患者中，15例出现脾切除失败或脾切除术后血小板减少复发。这15例患者中有9例还接受了免疫抑制剂治疗，其中4例治疗失败。在这15例治疗失败的患者中，有8例在随后3至12年未接受治疗的期间内血小板计数恢复正常或达到安全水平。对于某些治疗失败的成人特发性血小板减少性紫癜患者，满意的血小板水平自发恢复的频率可能对非常积极或长期的免疫抑制治疗尝试产生负面影响。
