Wisniewski H M, Sturman J A, Shek J W
Ann Neurol. 1980 Nov;8(5):479-90. doi: 10.1002/ana.410080505.
Aluminum chloride injected into the brains of developing rabbits produced profound neurofibrillary changes to neurons of spinal cord and cerebrum similar to those produced in adult rabbits, along with a variety of clinical symptoms with the exception of seizures. Approximately half of the rabbits survived for more than three weeks, and many survived for several months. Many rabbits with large numbers of neurofibrillary changes had no clinical signs and symptoms. The dynamics and topography of the neurofibrillary changes induced by aluminum chloride are described over a period of several months. Many neurofibrillary tangles were seen in neurons of spinal cord and cerebrum up to 60 days after injection of aluminum chloride. There was no obvious correlation between the degree of neurofibrillary changes and the severity of the clinical signs and symptoms. Animals examined at 85 and 100 days after injection of aluminum chloride had fewer neurofibrillary tangles of none at all, and apparently they had recovered from the neurofibrillary changes. This chronic animal model will allow better investigations of the biochemistry and pathology of neurofibrillary changes, and it will enable behavioral studies to be performed in animals with neurofibrillary changes.
向发育中的家兔脑内注射氯化铝，会使脊髓和大脑神经元产生严重的神经原纤维变化，类似于成年家兔所产生的变化，同时还会引发各种临床症状，但癫痫发作除外。大约一半的家兔存活超过三周，许多家兔存活了数月。许多有大量神经原纤维变化的家兔并无临床体征和症状。在几个月的时间里描述了由氯化铝诱导的神经原纤维变化的动态过程和部位。注射氯化铝后长达60天，在脊髓和大脑的神经元中可见许多神经原纤维缠结。神经原纤维变化的程度与临床体征和症状的严重程度之间没有明显的相关性。在注射氯化铝后85天和100天检查的动物，神经原纤维缠结较少或根本没有，显然它们已从神经原纤维变化中恢复。这种慢性动物模型将有助于更好地研究神经原纤维变化的生物化学和病理学，并且能够在有神经原纤维变化的动物中进行行为学研究。
