Kellaway P, Frost J D, Crawley J W
Ann Neurol. 1980 Nov;8(5):491-500. doi: 10.1002/ana.410080506.
Nineteen patients aged 4 to 44 years with generalized epilepsy and generalized 3 Hz spike-and-wave activity, were monitored for 24 or 36 hours on one to nine occasions to determine the time distribution of ictal and interictal electroencephalographic discharges and the consistency of the time patterns observed. Two patients with a low incidence of spike-and-wave activity had a random pattern of occurrence; the other 17 showed one of three types of time modulation. The latter can be explained by the interaction of two modulative processes, one with a period of about 100 minutes and the other of approximately 24 hours. The pattern observed depends on the phase angle of the two cyclic processes. Treatment with ethosuximide altered the pattern of time modulation, and eventually, when the spike-and-wave activity was reduced to a low level, the time distribution became random.
19名年龄在4至44岁之间的全身性癫痫患者，伴有全身性3赫兹棘慢波活动，接受了1至9次24或36小时的监测，以确定发作期和发作间期脑电图放电的时间分布以及所观察到的时间模式的一致性。两名棘慢波活动发生率较低的患者呈现随机发作模式；其他17名患者表现出三种时间调制类型之一。后者可以通过两个调制过程的相互作用来解释，一个周期约为100分钟，另一个约为24小时。观察到的模式取决于两个周期性过程的相位角。乙琥胺治疗改变了时间调制模式，最终，当棘慢波活动降至低水平时，时间分布变得随机。
