Müller-Oerlinghausen B
Arzneimittelforschung. 1980;30(8):1176-7.
Laboratory methods within a drug monitoring should provide maximum information with a minimum number of investigations. Greatest attention must be paid to the comparability of results between the institutions and over the whole length of the investigational period, i.e., possibly several years. This article concentrates on (a) selection of appropriate variables; (b) selection of appropriate methods and sampling times; (c) quality control and the problem of "normal values". A tentative selection of approx. 20 variables proposed for a drug monitoring in psychiatric patients. Clinico-chemical methods serve not only to detect adverse drug reactions but also to facilitate the interpretation of observed effects, e.g., in "risk-patients".
药物监测中的实验室方法应以最少的检测项目提供最大量的信息。必须高度重视各机构之间以及整个研究期间（可能长达数年）结果的可比性。本文着重于：（a）选择合适的变量；（b）选择合适的方法和采样时间；（c）质量控制以及“正常值”问题。初步选择了约20个变量用于精神科患者的药物监测。临床化学方法不仅用于检测药物不良反应，还有助于解释观察到的效应，例如在“高危患者”中。
