Kreutzberger A, Stratmann J
Arzneimittelforschung. 1980;30(8):1250-2.
Based on the concept of the anellated heterocycle as the common structural characteristic of a series of antiinflammatory agents, 5-nitrobenzotriazole (1) was caused to react with cinnamoyl chloride (2a) and 4-fluorobenzoyl chloride (2b). The structure of the end products 1-cinnamoyl-5-nitrobenzotriazole (3a) and 1-(4-fluorobenzoyl)-5-nitrobenzotriazole (3b) is supported spectroscopically. 3a exhibits marked antiinflammatory activity.
基于稠合杂环作为一系列抗炎剂的共同结构特征这一概念，使5-硝基苯并三唑（1）与肉桂酰氯（2a）和4-氟苯甲酰氯（2b）发生反应。最终产物1-肉桂酰基-5-硝基苯并三唑（3a）和1-（4-氟苯甲酰基）-5-硝基苯并三唑（3b）的结构通过光谱得到证实。3a表现出显著的抗炎活性。
