Antioedematous properties of benzoxazolinone-beta-amino-ketones.

Four chemically related benzoxazolinone-beta-amino-ketones act in vitro on the guinea pig ileum as histamine, serotonin, bradykinin and prostaglandin antagonists. These compounds decrease the rat carrageenan-induced paw oedema mediated by the above-mentioned mediators. With the aim of bringing out the acting mechanisms of that inhibition we studied their ability to inhibit various models of oedema induced either by the release or the injection of the involved mediators. It seems that there is a good enough correlation between the former results obtained in vitro and the present results.