Khayyal M T, el-Ghazaly M A, el-Khatib A S
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Egypt.
Drugs Exp Clin Res. 1993;19(5):197-203.
Propolis is a natural product produced by the honey bee. The extract contains amino acids, flavanoids, terpenes and cinnamic acid derivatives. In various in vitro models propolis extract was shown to inhibit platelet aggregation and to inhibit eicosanoid synthesis, suggesting that it might have potent antiinflammatory properties. A 13% aqueous extract was tested orally in three dose levels (1, 5 and 10 ml/kg) on the carrageenan rat paw oedema model and on adjuvant-induced arthritis in rats. In both models, the extract showed potent dose-related antiinflammatory activity, which compared well with that of diclofenac (as a reference standard). The extract was then tested on an isolated sensitized guinea pig lung preparation to study its effect on the release of prostaglandins, leukotrienes and histamine. It is concluded that propolis extract has potent antiinflammatory properties in vivo. Its activity can be well correlated with its effects on the release of various mediators of inflammation.
蜂胶是蜜蜂生产的一种天然产物。其提取物含有氨基酸、类黄酮、萜类化合物和肉桂酸衍生物。在各种体外模型中，蜂胶提取物显示出抑制血小板聚集和抑制类花生酸合成的作用，这表明它可能具有强大的抗炎特性。在角叉菜胶诱导的大鼠足爪水肿模型和佐剂诱导的大鼠关节炎模型上，对13%的水提取物进行了三种剂量水平（1、5和10毫升/千克）的口服测试。在这两种模型中，该提取物均显示出强大的剂量相关抗炎活性，与双氯芬酸（作为参考标准）相比效果良好。然后在离体致敏豚鼠肺制备物上测试该提取物，以研究其对前列腺素、白三烯和组胺释放的影响。得出的结论是，蜂胶提取物在体内具有强大的抗炎特性。其活性与其对各种炎症介质释放的影响密切相关。
