Boumsell L, Bernard A
J Immunol Methods. 1980;38(3-4):225-9. doi: 10.1016/0022-1759(80)90270-7.
While preparing monoclonal antibodies against human lymphocyte surface antigens, we compared two strains of mice, which had been genetically selected by Biozzi et al. (1970) for their high and low antibody responses to sheep erythrocytes. Biozzi et al. (1975) subsequently showed that these high and low responder strains (HR and LR) have a high and low antibody response to almost any antigen. We observed with the HR strain a huge increase in the number of hybrids secreting an antibody directed against human lymphocytes.
在制备抗人淋巴细胞表面抗原的单克隆抗体时，我们比较了两种小鼠品系，它们是由比奥齐等人（1970年）根据对绵羊红细胞的高抗体反应和低抗体反应进行基因选择的。比奥齐等人（1975年）随后表明，这些高反应品系和低反应品系（HR和LR）对几乎任何抗原都有高抗体反应和低抗体反应。我们观察到，在HR品系中，分泌针对人淋巴细胞抗体的杂交瘤数量大幅增加。
