Getz P, Malashenko A M, Surkova N I
Tsitol Genet. 1980 Jul-Aug;14(4):29-35.
Cyclophosphamide was given intraperitoneally in doses of 40, 80 and 160 mg/kg to C57BL/6 male mice. Cytogenetic effect in spermatogonia of A and B types and in pachytene spermatocytes was studied by the frequencies of chromosomes recorded in cells at the stage of diakinesis MI meiosis. In some cells cyclophosphamide induced structural chromosomal aberrations, including translocations and the disturbances of normal bivalent formation. The dose of 80 mg/kg induced translocations in spermatocytes with frequency 0.6% and appearance of 3% of translocation carriers in F1 generation. Three males were heterozygotes by the translocation of the Robertsonian type.
将环磷酰胺以40、80和160mg/kg的剂量腹腔注射给C57BL/6雄性小鼠。通过减数分裂MI双线期细胞中记录的染色体频率，研究了A型和B型精原细胞以及粗线期精母细胞的细胞遗传学效应。在一些细胞中，环磷酰胺诱导了染色体结构畸变，包括易位和正常二价体形成的紊乱。80mg/kg的剂量诱导精母细胞发生易位的频率为0.6%，并且在F1代中出现了3%的易位携带者。三只雄性小鼠为罗伯逊易位型杂合子。
