Goetz P, Malashenko A M, Surkova N
Folia Biol (Praha). 1980;26(5):289-97.
Single doses of 40, 80 and 160 mg of cyclophosphamide per kg body weight were administered intraperitoneally to C57BL/6 male mice. Cytogenetic analysis of spermatocytes at diakinesis/metaphase I, influenced as spermatogonia A and B and pachytene spermatocytes, showed the chromosomal damage. Cyclophosphamide induced structural chromosomal aberrations including translocations and interfered with the normal development of bivalents. The dose of 80 mg/kg yielded 0.6% spermatocytes with translocations and 3% translocation carriers in F1 males. Robertsonian translocations were detected in 3 males.
将每千克体重40、80和160毫克的环磷酰胺单剂量腹腔注射给C57BL/6雄性小鼠。对处于终变期/中期I的精母细胞进行细胞遗传学分析，这些精母细胞受到A型和B型精原细胞以及粗线期精母细胞的影响，结果显示出染色体损伤。环磷酰胺诱导了包括易位在内的结构性染色体畸变，并干扰了二价体的正常发育。80毫克/千克的剂量在F1雄性小鼠中产生了0.6%的带有易位的精母细胞和3%的易位携带者。在3只雄性小鼠中检测到了罗伯逊易位。
