Nesterenko V G, Gruner Sh, Rubakova E I, Babadzhanov A S
Biull Eksp Biol Med. 1980 Nov;90(11):588-90.
Antireceptor antibodies anti- (CBA-anti-C57BL/6) and anti-(C57BL/6-anti-BALB/c) were obtained in a heterologous system by immunization of rabbits with alloimmune mouse lymphocytes and intensive absorption of immune rabbit sera. In the complement-dependent cytotoxic assay, these antireceptor antibodies were able to lyse only T-lymphoblasts with corresponding idiotypic specificity but not T-lymphoblasts of other idiotypes and normal T- and B- lymphocytes of various strains. It was also shown that antireceptor antibodies specifically inhibit the lethal graft-versus-host disease after injection of allogenic parental spleen cells into irradiated F1-recipients. These results suggest that heterologous antireceptor antibodies are capable of inhibiting specifically the immune responses to allogenic transplantation antigens.
通过用同种免疫小鼠淋巴细胞免疫兔子并对免疫兔血清进行强化吸收，在异源系统中获得了抗受体抗体抗-（CBA抗C57BL/6）和抗-（C57BL/6抗BALB/c）。在补体依赖的细胞毒性试验中，这些抗受体抗体仅能裂解具有相应独特型特异性的T淋巴母细胞，而不能裂解其他独特型的T淋巴母细胞以及各种品系的正常T和B淋巴细胞。还表明，抗受体抗体在将同种异体亲代脾细胞注射到受照射的F1受体中后，能特异性抑制致死性移植物抗宿主病。这些结果表明，异源抗受体抗体能够特异性抑制对同种异体移植抗原的免疫反应。
