Bergerat J P, Drewinko B, Corry P, Barlogie B, Ho D H
Cancer Res. 1981 Jan;41(1):25-30.
cis-Dichlorodiammineplatinum(II) and 1-beta-D-arabinofuranosylcytosine display a dramatic synergistic effect when tested in simultaneous combination on LoVo cells, a human colon carcinoma cell line. 1-beta-D-Arabinofuranosylcytosine alone does not induce any cytotoxicity on LoVo cells even at high concentrations but is able to increase up to 1000 times the lethal effects of cis-dichlorodiammineplatinum(II). DNA elution experiments show that 1-beta-D-arabinofuranosylcytosine increases the amount of cis-dichlorodiammineplatinum(II)-induced DNA cross-links. The possible mechanisms of this effect are discussed, and some explanations are proposed.
顺式二氯二氨铂（II）和1-β-D-阿拉伯呋喃糖基胞嘧啶在对人结肠癌细胞系LoVo细胞进行联合测试时显示出显著的协同效应。单独使用1-β-D-阿拉伯呋喃糖基胞嘧啶即使在高浓度下也不会对LoVo细胞诱导任何细胞毒性，但能够将顺式二氯二氨铂（II）的致死效应提高多达1000倍。DNA洗脱实验表明，1-β-D-阿拉伯呋喃糖基胞嘧啶增加了顺式二氯二氨铂（II）诱导的DNA交联量。讨论了这种效应的可能机制，并提出了一些解释。
