Bergerat J P, Green C, Drewinko B
Cancer Biochem Biophys. 1979;3(4):173-80.
Combination effects of cis-dichlorodiammine platinum (II) (DDP) paired with 12 other antineoplastic agents were investigated on a human carcinoembryonic antigen producing colon carcinoma cell line in vitro. DDP was effective in increasing the killing efficiency of many different drugs. Supraadditive effects were noted with hydroxyurea, bleomycin, cis-acid, BCNU, adriamycin and mitomycin C, and a marked synergistic effect was noted with ara-C. DDP displayed simple additive effects wit 5-fluorouracil (5-FU), Ftorafur and methotrexate, and subadditive effects in simultaneous combination with vincristine. In view of its powerful cytotoxic effects on this particular cell line and of the supraadditive effects of its combinations with nitrosoureas and mitomycin C, DDP appears as a potentially useful antineoplastic agent for combination therapeutic regimens for human colon carcinoma.
在体外对一株产生人癌胚抗原的结肠癌细胞系研究了顺二氯二氨铂（II）（DDP）与其他12种抗肿瘤药物联用的效果。DDP能有效提高许多不同药物的杀伤效率。羟基脲、博来霉素、顺式酸、卡氮芥、阿霉素和丝裂霉素C呈现超相加效应，阿糖胞苷呈现显著的协同效应。DDP与5-氟尿嘧啶（5-FU）、呋氟尿嘧啶和甲氨蝶呤联用表现为简单相加效应，与长春新碱同时联用表现为次相加效应。鉴于DDP对该特定细胞系有强大的细胞毒性作用，以及它与亚硝基脲类和丝裂霉素C联用的超相加效应，DDP似乎是一种对人结肠癌联合治疗方案可能有用的抗肿瘤药物。
