前列腺素及其前体对动脉导管的扩张作用。
Dilatation of the ductus arteriosus by prostaglandins and prostaglandin's precursors.
作者信息
Momma K, Uemura S, Nishihara S, Ota Y
出版信息
Pediatr Res. 1980 Sep;14(9):1074-7. doi: 10.1203/00006450-198009000-00011.
We studied the effects of prostaglandins and their precursors in animal models. Rabbit ductus arteriosus constricted rapidly after delivery. PGE1, and PGE2, and arachidonic acid injected SC dilated the ductus over 60 min. Orogastrically administered PGE2 dilated the ductus for 3 hr. PGF2a and arachidonic acid showed weak ductus-dilating effects. Response of the ductus to PGE1 was most prominent in the first hr after birth. Pretreatment with indomethacin blocked the ductus-dilating effect of arachidonic acid.
我们在动物模型中研究了前列腺素及其前体的作用。兔动脉导管在出生后迅速收缩。皮下注射PGE1、PGE2和花生四烯酸可使动脉导管在60分钟内扩张。经口胃给予PGE2可使动脉导管扩张3小时。PGF2α和花生四烯酸显示出较弱的动脉导管扩张作用。动脉导管对PGE1的反应在出生后的第一小时最为显著。用吲哚美辛预处理可阻断花生四烯酸的动脉导管扩张作用。
Zotero 插件