Takizawa T, Ikeda Y, Arishima K, Yamamoto M, Togashi H, Namba Y, Somiya H, Eguchi Y
Department of Developmental Biotechnology, Azabu University, School of Veterinary Medicine, Kanagawa, Japan.
J Toxicol Sci. 1995 Feb;20(1):29-32. doi: 10.2131/jts.20.29.
The dilating effect of prostaglandin (PG) E1 and E2 on the once-constricted ductus arteriosus (DA) was examined in newborn rats. The animals were given subcutaneously PGs 3hr after caesarean delivery. The ratio of the DA to the pulmonary artery (PA) was determined 15, 30, 60, 90 and 180 min after injection. Both PGE1 and PGE2 dilated the DA for over 90 min. The maximal effect appeared 15 or 30 min after injection. The DA/PA ratio was significantly higher in PGE2 than in PGE1. In addition, another series of newborn rats were given subcutaneously PGE2 6 hr after caesarean delivery to examine the age-related changes in the DA-dilating effect. The DA/PA ratio was significantly decreased in 6-hr-old pups than in 3-hr-old pups. These findings indicate that both PGE1 and PGE2 have a dilating effect on the once-constricted DA and that the effect decreases with time.
在新生大鼠中研究了前列腺素（PG）E1和E2对曾经收缩的动脉导管（DA）的扩张作用。动物在剖宫产术后3小时皮下注射PGs。在注射后15、30、60、90和180分钟测定DA与肺动脉（PA）的比值。PGE1和PGE2均使DA扩张超过90分钟。最大作用出现在注射后15或30分钟。PGE2组的DA/PA比值显著高于PGE1组。此外，另一组新生大鼠在剖宫产术后6小时皮下注射PGE2，以研究DA扩张作用的年龄相关变化。6小时龄幼崽的DA/PA比值显著低于3小时龄幼崽。这些发现表明，PGE1和PGE2对曾经收缩的DA均有扩张作用，且该作用随时间减弱。
